CLT-007

CLT-007 is a naturally occuring peptide with neurotrophic and anti-angiogenic activity.  This peptide downregulates the expression of VEGF and also competes with VEGF for binding to VEGF-receptor 2.

CLT-007 inhibits VEGF production in normal and hypoxic conditions

Inhibition of VEGF expression by CLT-007 in bovine retinal capillary endothelial cells (BRCEC) and Müller cells under normal and hypoxic condition.
(A) BRCEC and Müller cells were exposed to 160 nM CLT-007 for 24 h. The intracellular VEGF levels were determined by Western blot analysis. The same membrane was stripped and reblotted with an anti-ß-actin antibody.  
(B) BRCEC were exposed to 1% oxygen with different concentrations of PEDF for 24 h.  The VEGF levels in the cell lysate were determined by Western blot analysis.  The same membrane was stripped and reblotted with the anti-ß actin antibody.